The objective: to study the frequency of the syndrome of "Low T3" in patients with decompensated heart failure (HF) on admission and its effect on the course of the disease.
Materials and methods. 188 patients with HF were included to the study (73 women and 115 men). The criterion for the syndrome "Low T3" was: free T3 (T3f) <2.0 pg / ml, with normal TSH and T4f. On admission the patients got standardized assessment, included a detailed medical history (concomitant diseases and medications), physical examination, parameters of clinical and biochemical blood tests, 12-lead electrocardiogram. A standardized ultrasound heart investigation was performed with calculations of the LV ejection fraction and LV dimensions. The serum level of hormones (TTG, free T3 and free T4) were determined using reagent kits (DS-ELISA-Tyroid). NT-proBNP in the blood serum was assessed by an enzyme immunoassay using Insulin ELISA reagent kits (DRG Instruments GmbH, Germany). The optical density was measured and the results were calculated by a semi-automatic immunoenzyme analyzer Immunochem 2100 (USA).
Results and discussion. The frequency of the syndrome of "Low T3" among patients with heart failure on admission is 27.7%. In patients with heart failure in the background of postinfarction cardiosclerosis, the concentration of natriuretic peptide is in a weak direct correlation with the frequency of the "Low T3" syndrome (r = +0.23, p <0.05) and in the reverse (medium degree) with serum free triiodothyronine (T3f) (r = - 0.46, p <0.05). Patients with HF, flows in the background of the syndrome of "Low T3", on admission have: 10.5% lower LVEF (p <0.05); and 5.7% higher final diastolic LV size (p <0.05) and heart rate (by 14.3%, p <0.05), less glomerular filtration rate (by 10.6%, p <0.05) and the level of hemoglobin of the blood (by 6.5%, p <0.05), compared with these values for patients without peripheral distyroidism.
Conclusions. The frequency of the "Low T3" syndrome with HF is 27.7%. In HF the natriuretic peptide is in direct correlation with the frequency of the "Low T3" syndrome and in reverse with the level of T3f. Patients with HF on admission have: a lower LVEF; higher final diastolic LV size and heart rate; less glomerular filtration rate and hemoglobin level of blood.
Key words: heart failure, triiodothyronine, syndrome of "Low T3, frequency, clinical course.
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